lossofheterozygosityloh

When the loss of heterozygosity involves the normal allele, it creates a cell that is more likely to show malignant growth if the altered gene is a tumor ...

LOH (short for “loss of heterozygosity”) refers to a type of mutation that results in the loss of one copy of a segment of DNA (typically containing a gene ...

Loss of heterozygosity (LOH) is a type of genetic abnormality in diploid organisms in which one copy of an entire gene and its surrounding chromosomal ...

Genomic Loss of Heterozygosity (LOH) or genomic instability is often related to defective homologous recombination repair mechanisms.

Loss of heterozygosity (LOH) is a common form of allelic imbalance by which a heterozygous somatic cell becomes homozygous because one of the two alleles gets ...

由 CA Nichols 著作 · 2020 · 被引用 71 次 — Hundreds to thousands of non-driver genes undergo loss of heterozygosity (LOH) events per tumor, generating discrete differences between tumor ...

由 GL Ryland 著作 · 2015 · 被引用 160 次 — Loss of heterozygosity (LOH) is a common genetic event in cancer development, and is known to be involved in the somatic loss of wild-type ...

由 GL Ryland 著作 · 2015 · 被引用 160 次 — Background. Loss of heterozygosity (LOH) is a common genetic event in cancer development, and is known to be involved in the somatic loss of ...

由 X Zhang 著作 · 2021 · 被引用 34 次 — Loss of heterozygosity (LOH) is a common genetic event in the development of cancer and is known to play an essential role in the somatic loss ...

2023年11月15日 — In some cases, loss of heterozygosity can contribute to the development of cancer. LOH of particular genes is associated with specific cancer ...